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GKT136901
CAS No. 955272-06-7
GKT136901( AK120765 )
Catalog No. M21598 CAS No. 955272-06-7
GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 35 | In Stock |
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| 25MG | 65 | In Stock |
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| 50MG | 91 | In Stock |
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| 100MG | 126 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGKT136901
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NoteResearch use only, not for human use.
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Brief DescriptionGKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.
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DescriptionGKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.
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In Vitro——
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In VivoAnimal Model:Male db/db and db/m mice (8 weeks) Dosage:30, 90 mg/kg Administration:Daily p.o. for 16 weeks Result:Reduced albuminuria, thiobarbituric acid-reacting substances (TBARS) and renal ERK1/2 phosphorylation and preserved renal structure in diabetic mice.Had no effect on plasma glucose, BP (blood pressure), and body weight.
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SynonymsAK120765
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorNOX1
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Research Area——
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Indication——
Chemical Information
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CAS Number955272-06-7
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Formula Weight366.8
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Molecular FormulaC19H15ClN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (90.87 mM)
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SMILESCc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
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Chemical Name2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[43-c]pyridine-36-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.S Schildknecht A Weber H R Gerding.The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite.Curr Med Chem. 2014;21(3):365-76.
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