Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - NADPH - GKT136901

GKT136901

CAS No. 955272-06-7

GKT136901( AK120765 )

Catalog No. M21598 CAS No. 955272-06-7

GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
10MG 35 In Stock
25MG 65 In Stock
50MG 91 In Stock
100MG 126 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GKT136901
  • Note
    Research use only, not for human use.
  • Brief Description
    GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.
  • Description
    GKT136901 is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male db/db and db/m mice (8 weeks) Dosage:30, 90 mg/kg Administration:Daily p.o. for 16 weeks Result:Reduced albuminuria, thiobarbituric acid-reacting substances (TBARS) and renal ERK1/2 phosphorylation and preserved renal structure in diabetic mice.Had no effect on plasma glucose, BP (blood pressure), and body weight.
  • Synonyms
    AK120765
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NADPH
  • Recptor
    NOX1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    955272-06-7
  • Formula Weight
    366.8
  • Molecular Formula
    C19H15ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (90.87 mM)
  • SMILES
    Cc1n(Cc2ccccn2)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12
  • Chemical Name
    2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1H-pyrazolo[43-c]pyridine-36-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.S Schildknecht A Weber H R Gerding.The NOX1/4 Inhibitor GKT136901 as Selective and Direct Scavenger of Peroxynitrite.Curr Med Chem. 2014;21(3):365-76.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 2-HBA

    2-HBA a synthetic analog of curcumin is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.

  • APX-115

    APX-115 (Ewha 18278)?is a first-in-class, orally active, pan-NADPH oxidase (Nox) inhibitor with Ki of 1.08, 0.57, 0.63 nM for Nox1, Nox2, and Nox4, respectively.

  • GLX351322

    GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.

Sign In Join Free