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Gentamicin
CAS No. 1403-66-3
Gentamicin( —— )
Catalog No. M34079 CAS No. 1403-66-3
Gentamicin (Centicin) is a broad-spectrum aminoglycoside antibiotic with antibacterial activity, inhibiting the growth of Gram-positive and Gram-negative bacteria, and can be used to study ocular infections.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 104 | In Stock |
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| 50MG | 150 | In Stock |
|
| 100MG | 215 | In Stock |
|
| 200MG | 320 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGentamicin
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NoteResearch use only, not for human use.
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Brief DescriptionGentamicin (Centicin) is a broad-spectrum aminoglycoside antibiotic with antibacterial activity, inhibiting the growth of Gram-positive and Gram-negative bacteria, and can be used to study ocular infections.
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DescriptionGentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM.
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In VitroGentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication.Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin.Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures. Gentamicin is produced by various species of the genus Micromonospora. Gentamicin C1a binds in the major groove of the A-site of the RNA.
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In VivoGentamicin (oral and injectable forms) exhibits effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model.Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse.
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntibiotic
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RecptorAntibiotic | Antibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number1403-66-3
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Formula Weight477.60(Avervage)
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Molecular FormulaC21H43N5O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCN[C@@H]1[C@H]([C@H](OC[C@@]1(O)C)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@H]3O[C@@H](CC[C@H]3N)CN)N)N)O.CN[C@@H]4[C@H]([C@H](OC[C@@]4(O)C)O[C@H]5[C@@H](C[C@@H]([C@H]([C@@H]5O)O[C@H]6O[C@H]([C@H](N)C)CC[C@H]6N)N)N)O.CN[C@@H]([C@@H]7CC[C@H]([C@H](O7)O[C@@H]8[C@H](C[C@H]([C@@H]([C@H]8O)O[C@H]9OC[C@](O)([C@@H]([C@H]9O)NC)C)N)N)N)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xu W, et al. A rapid and sensitive method for kinetic study and activity assay of DNase I in vitro based on a GO-quenched hairpin probe. Anal Bioanal Chem. 2016 May;408(14):3801-9.?
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