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GX 201

CAS No. 1788071-27-1

GX 201( —— )

Catalog No. M37645 CAS No. 1788071-27-1

GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GX 201
  • Note
    Research use only, not for human use.
  • Brief Description
    GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.
  • Description
    GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Wild-Type Mice.Dosage:0.3, 1, 3 mg/kg.Administration:Orally, once.Result:Produced a dose-dependent inhibition of the nociceptive events.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1788071-27-1
  • Formula Weight
    563
  • Molecular Formula
    C25H27ClF4N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (111.01 mM; Ultrasonic )
  • SMILES
    CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(ccc3Cl)C(F)(F)F)CC2)cc1F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Girish Bankar, et al. Selective Na V 1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Rep. 2018 Sep 18;24(12):3133-3145.?
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