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Home - Products - Metabolic Enzyme/Protease - Transferase - GGsTop

GGsTop

CAS No. 926281-37-0

GGsTop( —— )

Catalog No. M33367 CAS No. 926281-37-0

GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GGsTop
  • Note
    Research use only, not for human use.
  • Brief Description
    GGsTop (Nahlsgen) is a highly selective and irreversible inhibitor of γ-glutamyltransferase (GGT) with antiaging activity.
  • Description
    GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ?glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively. GGsTop protects hepatic ischemia-reperfusion injury in rat model.
  • In Vitro
    GGsTop (Nahlsgen; Compound 5a) is a potent, highly selective and irreversible γ?glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively.GGsTop is non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant.
  • In Vivo
    GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats. GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats.Animal Model:Male rats (9 week old)Dosage:1 mg/kg Administration:Injected into the inferior vena cava for 12, 24, 48 h Result:Lowered the serum levels of ALT, AST, prevented the increase of serum γ-GT levels in IR-GGsTop group.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Transferase
  • Recptor
    Transferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    926281-37-0
  • Formula Weight
    331.26
  • Molecular Formula
    C13H18NO7P
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (301.88 mM; Ultrasonic )
  • SMILES
    O=C(O)CC=1C=CC=C(OP(=O)(OC)CCC(N)C(=O)O)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Han L, et al. Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase. Biochemistry. 2007 Feb 6;46(5):1432-47.?
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