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Home - Products - Metabolic Enzyme/Protease - P450 - Furafylline

Furafylline

CAS No. 80288-49-9

Furafylline( —— )

Catalog No. M20761 CAS No. 80288-49-9

Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Furafylline
  • Note
    Research use only, not for human use.
  • Brief Description
    Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
  • Description
    Furafylline is a selective inhibitor of human cytochrome P450 (CYP)1A2 (IC50 : 0.07 μM)
  • In Vitro
    ——
  • In Vivo
    Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    CYP450
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    80288-49-9
  • Formula Weight
    260.25
  • Molecular Formula
    C12H12N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL (48.03 mM)
  • SMILES
    Cc1nc2n(Cc3ccco3)c(=O)n(C)c(=O)c2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sesardic D Boobis A R Murray B P et al. Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.[J]. British Journal of Clinical Pharmacology 1990 29(6):651-663.
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