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Dovramilast
CAS No. 340019-69-4
Dovramilast( —— )
Catalog No. M35691 CAS No. 340019-69-4
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor that reduces the production of pro-inflammatory mediators and cytokines.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 192 | In Stock |
|
| 5MG | 297 | In Stock |
|
| 10MG | 471 | In Stock |
|
| 25MG | 877 | In Stock |
|
| 50MG | 1371 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDovramilast
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NoteResearch use only, not for human use.
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Brief DescriptionDovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor that reduces the production of pro-inflammatory mediators and cytokines.
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DescriptionDovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).
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In Vitro——
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In VivoDovramilast (oral gavage, 5, 25, or 50 mg/kg, single) significantly improves antibiotic-mediated bacterial killing and reduces lung pathology. Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice.Animal Model:B6D2F1 mice Dosage:5, 25, or 50 mg/kg Administration:oral, 5, 25, or 50 mg/kg, single Result:Reduced PDE4 expression in mtb-infected mouse lungs.Animal Model:B6D2F1 mice Dosage:5, 25, or 50 mg/kg Administration:oral gavage, 5, 25, or 50 mg/kg, single Result:Improved antibiotic-mediated bacterial killing and reduced lung pathology.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number340019-69-4
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Formula Weight472.55
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Molecular FormulaC24H28N2O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (52.90 mM; Ultrasonic (<60°C)
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SMILESCCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1Cc2cccc(NC(=O)C3CC3)c2C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.
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