Dienogest( STS 557 )

Catalog No. M15509 CAS No. 65928-58-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dienogest
Note

Research use only, not for human use.
Brief Description

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
Description

Dienogest is an orally active synthetic progesterone, used for contraception and the treatment of endometriosis.
In Vitro

Cell Viability Assay Cell Line:EM-PR cells Concentration:0.01-1 μM Incubation Time:24 h Result:Inhibited PGE2 production and suppressed NF-κB binding activity in the spheroid culture. Cell Viability Assay Cell Line:EM-PR cells Concentration:0.1 μM Incubation Time:24 h Result:Decreased the mRNA expression of the PGE2 synthases COX-2 and mPGES-1 compared with the respective control.Inhibited aromatase mRNA expression and increased the expression of COUP-TFII mRNA level.
In Vivo

Animal Model:Female Wistar rats (8 to 10-week-old; 180-220 g; rat endometrial autograft model).Dosage:1 mg/kg Administration:Oral administration; once daily for 14 days.Result:Showed significant suppression of angiogenesis of endometrial autografts, as indicated by the reduced size of the microvascular network and decreased microvessel density.Significantly reduced the level of perivascular α-smooth muscle actin within endometrial grafts.
Synonyms

STS 557
Pathway

Endocrinology/Hormones
Target

Estrogen Receptor/ERR
Recptor

ER
Research Area

Endocrinology
Indication

——

CAS Number

65928-58-7
Formula Weight

311.42
Molecular Formula

C20H25NO2
Purity

>98% (HPLC)
Solubility

DMSO: 62 mg/mL (199.08 mM)
SMILES

N#CC[C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3CC[C@]12C)=O
Chemical Name

2-((8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile

1.Sasagawa S, et al. Steroids, 2008, 73(2), 222-23

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