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LY88074
CAS No. 177744-96-6
LY88074( —— )
Catalog No. M33002 CAS No. 177744-96-6
LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 198 | In Stock |
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| 5MG | 199 | In Stock |
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| 10MG | 300 | In Stock |
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| 25MG | 514 | In Stock |
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| 50MG | 710 | In Stock |
|
| 100MG | 930 | In Stock |
|
| 200MG | 1256 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY88074
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NoteResearch use only, not for human use.
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Brief DescriptionLY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.
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DescriptionLY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner.
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In VitroRemoval of the aminoethylpiperdine moiety, as in LY88074 (Compound 88074), reduces bone binding, compared to Raloxifene. The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene.
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In Vivo——
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen/progestogen Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number177744-96-6
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Formula Weight362.4
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Molecular FormulaC21H14O4S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bivi N, et al. Structural features underlying raloxifene's biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.?
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