Cart
sales@molnova.com
DUPA
CAS No. 302941-52-2
DUPA( (2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | N,N''-Carbonylbis[L-glutamic acid] )
Catalog No. M27072 CAS No. 302941-52-2
DUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 33 | Get Quote |
|
| 5MG | 53 | Get Quote |
|
| 10MG | 87 | Get Quote |
|
| 25MG | 158 | Get Quote |
|
| 50MG | 267 | Get Quote |
|
| 100MG | 410 | Get Quote |
|
| 200MG | 591 | Get Quote |
|
| 500MG | 888 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameDUPA
-
NoteResearch use only, not for human use.
-
Brief DescriptionDUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
-
DescriptionDUPA is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.(In Vitro):After binding to a DUPA-drug conjugate, PSMA internalizes, unloads the conjugate, and returns to the surface.(In Vivo):As determined by loss of body weight and death of treated mice,DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity.
-
In VitroDUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures.
-
In VivoThe DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice.
-
Synonyms(2S,2'S)-2,2'-Carbonylbis(Azanediyl)Dipentanedioic Acid | N,N''-Carbonylbis[L-glutamic acid]
-
PathwayOthers
-
TargetOther Targets
-
Recptor20S proteasome
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number302941-52-2
-
Formula Weight320.254
-
Molecular FormulaC11H16N2O9
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 300 mg/mL (936.77 mM)
-
SMILES[H][C@@](CCC(O)=O)(NC(=O)N[C@@]([H])(CCC(O)=O)C(O)=O)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Encouse B Golden, et al. Green Tea Polyphenols Block the Anticancer Effects of Bortezomib and Other Boronic Acid-Based Proteasome Inhibitors. Blood. 2009 Jun 4;113(23):5927-37.
molnova catalog
related products
-
Catechin 7,3-di-O-be...
The herbs of Spiraea hypericifolia L.
-
Difopein TFA (396834...
Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells.
-
Sanggenone H
Sanggenone H may have antiphlogistic activity, it attenuated the secretion of TNF-α± and IL-1α2 and inhibited the NF-κB nuclear translocation in LPS-stimulated macrophages.
