AUDA

Research use only, not for human use.

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes respectively).

AUDA (0.3-10 μg/mL; 48 hours) dose-dependently suppresses the proliferation of rat VSMCs exposed to PDGF. AUDA (0.3-10 μg/mL; 30 min) dose-dependently upregulats COX-2 expression. AUDA (10, 50 and 100 μM) augments the migratory ability of HCAECs in a dose-dependent manner. AUDA significantly increases the adhesion ability of HCAECs. Cell Proliferation AssayCell Line:Vascular smooth muscle cell (VSMC)Concentration:0.3, 1, 3, 10 μg/mLIncubation Time:48 hoursResult:Dose-dependently suppressed the proliferation of rat VSMCs exposed to PDGF. Western Blot AnalysisCell Line:VSMC Concentration:1, 3, 10, 30 μg/mL Incubation Time:30 minResult:Dose-dependently upregulated COX-2 expression.

AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels. Animal Model:Male (wild-type) C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g) Dosage:10 mg/kg Administration:i.p.; 14 days Result:Reduced TNF-α, MMP-9 and IL-1β expression levels.

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Others

Other Targets

sEH

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479413-70-2

392.6

C23H40N2O3

>98% (HPLC)

DMSO:1mg/ml(2.55mM)

O=C(O)CCCCCCCCCCCNC(=O)NC12CC3CC(CC(C3)C1)C2

12-[(Adamantan-1-ylcarbamoyl)amino]dodecanoic acid

(-20℃)

With Ice Pack

≥ 2 years