DHODH-IN-13( —— )

Catalog No. M26154 CAS No. 1364791-86-5

DHODH-IN-13 is the hydroxyfuran analogue of A771726.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

DHODH-IN-13
Note

Research use only, not for human use.
Brief Description

DHODH-IN-13 is the hydroxyfuran analogue of A771726.
Description

DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis.
In Vitro

DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726 and is stable under physiological conditions. When DHODH-IN-13 is docked in silico at the DHODH active site, a BQN-like pose is obtained with the deprotonated furazan hydroxyl facing Arg136 instead of Tyr356, thus effectively mimicking the carboxyl group of BQN and related compounds.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

E3 Ligase Ligand-Linker Conjugate
Research Area

——
Indication

——

Chemical Information

CAS Number

1364791-86-5
Formula Weight

273.171
Molecular Formula

C10H6F3N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

FC(F)(F)c1ccc(NC(=O)c2no[nH]c2=O)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

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