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DBCO-PEG5-NHS ester

CAS No. 2144395-59-3

DBCO-PEG5-NHS ester( —— )

Catalog No. M33335 CAS No. 2144395-59-3

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DBCO-PEG5-NHS ester
  • Note
    Research use only, not for human use.
  • Brief Description
    DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.
  • Description
    DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC Linker
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2144395-59-3
  • Formula Weight
    693.74
  • Molecular Formula
    C36H43N3O11
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (144.15 mM)
  • SMILES
    O=C(ON1C(=O)CCC1=O)CCOCCOCCOCCOCCOCCNC(=O)CCC(=O)N2C=3C=CC=CC3C#CC=4C=CC=CC4C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Craig L. Duvall, et al. Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing. US20180064749A1.
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