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Cyclizine hydrochloride
CAS No. 303-25-3
Cyclizine hydrochloride( —— )
Catalog No. M18392 CAS No. 303-25-3
Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 45 | In Stock |
|
| 200MG | 57 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCyclizine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo.
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DescriptionCyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo.(In Vitro):Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.(In Vivo):Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner.
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In VitroCyclizine (100 μM) hydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine hydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
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In VivoCyclizine (1-10 mg/kg) hydrochloride enhances locomotor activity of mice in a dose-dependent manner.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeurokinin Receptor
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RecptorOthers
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number303-25-3
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Formula Weight302.85
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Molecular FormulaC18H22N2·HCl
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Neurokinin A(4-10)
Neurokinin A (4-10) is a tachykinin NK2 receptor agonist. A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle.
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Eledoisin
Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994.
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NIH-12848
NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
