Cart
sales@molnova.com
Home - Products - Proteasome/Ubiquitin - E1 - Cbl-b-IN-3

Cbl-b-IN-3

CAS No. 2573775-59-2

Cbl-b-IN-3( —— )

Catalog No. M35743 CAS No. 2573775-59-2

Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 582 Get Quote
5MG 869 Get Quote
10MG 1188 Get Quote
25MG 1702 Get Quote
50MG 2282 Get Quote
100MG 3033 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Cbl-b-IN-3
  • Note
    Research use only, not for human use.
  • Brief Description
    Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).
  • Description
    Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.
  • In Vitro
    Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E1
  • Recptor
    E1/E2/E3 Enzyme
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2573775-59-2
  • Formula Weight
    537.62
  • Molecular Formula
    C30H34F3N5O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (186.00 mM; Ultrasonic )
  • SMILES
    CN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • UC-764864

    UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, inhibits innate immune signaling and induces cytotoxic effects in MDS/AML cell lines and primary cells. In addition, UC-764864 reduces the ubiquitination status of UBE2N and can be used to study leukemia.

  • Cbl-b-IN-3

    Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).

  • PYR-41

    PYR-41 is a selective, cell-permeable inhibitor of ubiquitin-activating enzyme (E1).

Sign In Join Free