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UC-764864
CAS No. 278806-03-4
UC-764864( —— )
Catalog No. M37227 CAS No. 278806-03-4
UC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, inhibits innate immune signaling and induces cytotoxic effects in MDS/AML cell lines and primary cells. In addition, UC-764864 reduces the ubiquitination status of UBE2N and can be used to study leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 250 | In Stock |
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| 10MG | 455 | In Stock |
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| 25MG | 750 | In Stock |
|
| 50MG | 1004 | In Stock |
|
| 100MG | 1358 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameUC-764864
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NoteResearch use only, not for human use.
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Brief DescriptionUC-764864 is a selective UBE2N inhibitor that blocks E1-UBE2N thioester transfer, inhibits innate immune signaling and induces cytotoxic effects in MDS/AML cell lines and primary cells. In addition, UC-764864 reduces the ubiquitination status of UBE2N and can be used to study leukemia.
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DescriptionUC-764864 is a UBE2N inhibitor. UC-764864 inhibits UBE2N enzymatic activity. UC-764864 has cytotoxic effects and inhibition of UBE2N-dependent signaling in leukemic cells. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetE1
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RecptorE1/E2/E3 Enzyme
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Research Area——
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Indication——
Chemical Information
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CAS Number278806-03-4
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Formula Weight322.42
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Molecular FormulaC19H18N2OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C=CSC1=NC=2C=C(C=CC2N1)C)C3=CC=C(C=C3)CC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barreyro L, et al. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Sci Transl Med. 2022 Mar 9;14(635):eabb7695.?
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