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Cbl-b-IN-3
CAS No. 2573775-59-2
Cbl-b-IN-3( —— )
Catalog No. M35743 CAS No. 2573775-59-2
Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 176 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 202 | In Stock |
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| 25MG | 385 | In Stock |
|
| 50MG | 578 | In Stock |
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| 100MG | 923 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCbl-b-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionCbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).
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DescriptionCbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation.
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In VitroCbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetE1
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RecptorE1/E2/E3 Enzyme
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Research Area——
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Indication——
Chemical Information
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CAS Number2573775-59-2
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Formula Weight537.62
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Molecular FormulaC30H34F3N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (186.00 mM; Ultrasonic )
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SMILESCN1C([C@]2(C[C@@H](C)C2)C3=CC(=CC=C3)N4CC=5C(C4=O)=CC(CN6C[C@@H](C)CCC6)=CC5C(F)(F)F)=NN=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.
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