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Home - Products - Metabolic Enzyme/Protease - P450 - CYP17-IN-1

CYP17-IN-1

CAS No. 2093317-51-0

CYP17-IN-1( —— )

Catalog No. M26134 CAS No. 2093317-51-0

CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CYP17-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.
  • Description
    CYP17-IN-1 is an effective oral CYP17 inhibitor that can inhibit CYP17 in rats and humans with IC50 of 15.8 and 20.1 nM.(In Vitro):The IC50 value of CYP17-IN-1 for CYP3A4 is 8.5 μM.(In Vivo):CYP17-IN-1 dose-dependently reduced plasma testosterone levels in Sprague-Dawley rats.
  • In Vitro
    CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 μM against CYP3A4.
  • In Vivo
    CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    P450
  • Recptor
    carbonic anhydrase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2093317-51-0
  • Formula Weight
    312.41
  • Molecular Formula
    C18H17FN2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1ccncc1CN1CCc2c(C1)sc1ccc(F)cc21
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554.
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