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CVT-12012

CAS No. 1018675-35-8

CVT-12012( —— )

Catalog No. M20507 CAS No. 1018675-35-8

CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CVT-12012
  • Note
    Research use only, not for human use.
  • Brief Description
    CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
  • Description
    CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
  • In Vitro
    CVT-12012 (Compound 5b) displays the highest potency in both the microsomal and the HEPG2 SCD assays (IC50 38 nM and 6.1 nM, respectively) compared to the other methyl-substituted compounds.
  • In Vivo
    In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    SCD
  • Recptor
    human HEPG2|rat microsomal
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1018675-35-8
  • Formula Weight
    434.41
  • Molecular Formula
    C21H21F3N4O3?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (287.75 mM)
  • SMILES
    Cc1nc2ccc(NCc3cccc(c3)C(F)(F)F)cc2n(CCNC(=O)CO)c1=O
  • Chemical Name
    2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-12-dihydroquinoxalin-1-yl)ethyl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Koltun D O Vasilevich N I Parkhill E Q et al. Orally bioavailable liver-selective stearoyl-CoA desaturase (SCD) inhibitors[J]. Bioorganic and Medicinal Chemistry Letters 2009 19(11):3050-3053.
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