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Home - Products - Metabolic Enzyme/Protease - Retinoid Receptor - BMS493

BMS493

CAS No. 215030-90-3

BMS493( —— )

Catalog No. M33296 CAS No. 215030-90-3

BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BMS493
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.
  • Description
    BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation. BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    Cell Viability Assay Cell Line:ALDHhi UCB cells Concentration:100 nM Incubation Time:6 days Result:Showed a twofold increase in the number of ALDHhi cells available for transplantation compared with untreated controls.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Retinoid Receptor
  • Recptor
    Retinoid Receptor | Phospholipase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    215030-90-3
  • Formula Weight
    404.5
  • Molecular Formula
    C29H24O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (123.61 mM; Ultrasonic )
  • SMILES
    CC1(C)CC=C(C#Cc2ccccc2)c2cc(\C=C\c3ccc(cc3)C(O)=O)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Elgamal RM, et al. BMS 493 Modulates Retinoic Acid-Induced Differentiation During Expansion of Human Hematopoietic Progenitor Cells for Islet Regeneration. Stem Cells Dev. 2018 Aug 1;27(15):1062-1075.?
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