Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Potassium Channel - BMS-919373

BMS-919373

CAS No. 1272353-82-8

BMS-919373( BMS919373 )

Catalog No. M11139 CAS No. 1272353-82-8

BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 536 Get Quote
5MG 873 Get Quote
10MG 1161 Get Quote
25MG 1755 Get Quote
50MG 2358 Get Quote
100MG 3177 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BMS-919373
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM.
  • Description
    BMS-919373 is a potent I(Kur)/Kv1.5 channel blocker with IC50 of 50 nM, with selectivity versus hERG, Na, Ca channels and reduced the level of brain penetration; shows robust anti- arrhythmia effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile.Heart Arrhythmia Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BMS919373
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Cardiovascular Disease
  • Indication
    Heart Arrhythmia

Chemical Information

  • CAS Number
    1272353-82-8
  • Formula Weight
    468.535
  • Molecular Formula
    C25H20N6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C(C=C1)C2=C3C(=CC=C2)N=C(N=C3NCC4=CC=CC=N4)C5=CC(=CN=C5)S(=O)(=O)N
  • Chemical Name
    5-(5-phenyl-4-((pyridin-2-ylmethyl)amino)quinazolin-2-yl)pyridine-3-sulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gunaga P, et al. J Med Chem. 2017 May 11;60(9):3795-3803.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • GW 542573X

    GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.

  • PAP-1

    PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).

  • Tertiapin-Q

    A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively) and is selective over Kir2.1 channels. Derivative tertiapin LQ also available.

Sign In Join Free