BMS-204352

CAS No. 187523-35-9

BMS-204352( BMS 204352 | Maxipost | BMS204352 )

Catalog No. M12907 CAS No. 187523-35-9

A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 115 Get Quote
10MG 170 Get Quote
25MG 357 Get Quote
50MG 533 Get Quote
100MG 761 Get Quote
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Biological Information

  • Product Name
    BMS-204352
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches.
  • Description
    A potent and effective calcium-sensitive opener of maxi-K potassium channels (maxi-K) with EC50 of 392 nM at -48.4 mV in HEK293 isolated outside-out membrane patches; a potent and effective opener of two important subtypes of neuronal potassium channels, K(Ca) channels and KCNQ channels, strongly activates the voltage-gated K+ channel KCNQ5 with EC50 of 2.4 uM; shows significant levels of cortical neuroprotection in rat models of permanent large-vessel stroke.Stroke Phase 3 Discontinued.
  • In Vitro
    Flindokalner (BMS-204352) (10 μM) inhibits Kv7.4and Kv7.5 with Kis of 230 and 605 μM, respectively.Flindokalner (1-10 μM) causes inhibition of the Ca2+ current in a dose-dependent manner, with a Kd of 6 μM and a Hill coefficient of 1.33. Flindokalnerinhibits cardiac L-type Ca2+ channels in a direct manner, without affecting BKCa channels or intracellular signal transduction, in freshly isolated rat ventricular myocytes.
  • In Vivo
    Flindokalner (BMS-204352) (3-30 mg/kg; i.p.) induces a dose-dependent anxiolytic effect.In shock-based conditioned model of anxiety in male Wistar rats, Flindokalner (3-60 mg/kg; i.p.) engenderes an anxiolytic profile. Animal Model:Female NMRI or male C57 mice (20-25 g) (Anxiolytic Models)Dosage:i.p.Administration:3, 10, 30 mg/kg Result:Significantly and dose dependently increased time spent in the open areas, reduced latency to enter an open area, and increased the number of entries in to the open areas in Zero Maze.
  • Synonyms
    BMS 204352 | Maxipost | BMS204352
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Stroke

Chemical Information

  • CAS Number
    187523-35-9
  • Formula Weight
    359.7
  • Molecular Formula
    C16H10ClF4NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (278.01 mM)
  • SMILES
    O=C1NC2=C(C=CC(C(F)(F)F)=C2)[C@@]1(C3=CC(Cl)=CC=C3OC)F
  • Chemical Name
    (3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gribkoff VK, et al. Nat Med. 2001 Apr;7(4):471-7. 2. Schr?der RL, et al. Neuropharmacology. 2001 Jun;40(7):888-98. 3. Dupuis DS, et al. Eur J Pharmacol. 2002 Feb 22;437(3):129-37. 4. Hewawasam P, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1023-6.
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