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Arterolane

CAS No. 664338-39-0

Arterolane( OZ277 | RBx 11160 )

Catalog No. M15532 CAS No. 664338-39-0

Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Arterolane
  • Note
    Research use only, not for human use.
  • Brief Description
    Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.
  • Description
    Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.Parasite Infection Phase 2 Discontinued.
  • In Vitro
    Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively.
  • In Vivo
    ——
  • Synonyms
    OZ277 | RBx 11160
  • Pathway
    Microbiology/Virology
  • Target
    Parasite
  • Recptor
    Parasite
  • Research Area
    Infection
  • Indication
    Parasite Infection

Chemical Information

  • CAS Number
    664338-39-0
  • Formula Weight
    392.54
  • Molecular Formula
    C22H36N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 254.76 mM
  • SMILES
    O=C(NCC(C)(N)C)CC(CC1)CCC21OC3(OO2)C4CC5CC(C4)CC3C5
  • Chemical Name
    N-(2-amino-2-methylpropyl)-2-{dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-cyclohexane]-4''-yl}acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kreidenweiss A, et al. Antimicrob Agents Chemother. 2006 Apr;50(4):1535-7. 2. Vennerstrom JL, et al. Nature. 2004 Aug 19;430(7002):900-4. 3. Maerki S, et al. J Antimicrob Chemother. 2006 Jul;58(1):52-8. 4. Snyder C, et al. Exp Parasitol. 2007 Mar;115(3):296-300.
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