AZD3839

Research use only, not for human use.

AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM.

AZD3839 (AZD-3839, AZD 3839) is a potent and selective BACE1 inhibitor with Ki of 26 nM, displays 14- and >1000-fold selectivity against BACE2 and cathepsin D; inhibits Aβ (Aβ40 IC50=4.8 nM) and sAPPβ release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons; exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate; demonstrates significant reduction of β-amyloid peptides in mouse brain.Alzheimer Disease Phase 1 Discontinued.

——

——

AZD-3839 | AZD 3839

Metabolic Enzyme/Protease

BACE

BACE1

Neurological Disease

Alzheimer Disease

1227163-84-9

431.4125

C24H16F3N5

>98% (HPLC)

10 mM in DMSO

NC1=N[C@@](C2=CC=CC(C3=CN=CN=C3)=C2)(C4=CC(C(F)F)=NC=C4)C5=C1C(F)=CC=C5

1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)-

(-20℃)

With Ice Pack

≥ 2 years