ARS-1323

CAS No. 1698024-73-5

ARS-1323( ARS1323 )

Catalog No. M12590 CAS No. 1698024-73-5

ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 115 Get Quote
10MG 192 Get Quote
25MG 295 Get Quote
50MG 385 Get Quote
100MG 561 Get Quote
500MG 1152 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ARS-1323
  • Note
    Research use only, not for human use.
  • Brief Description
    ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor.
  • Description
    ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ARS1323
  • Pathway
    MAPK/ERK Signaling
  • Target
    Ras
  • Recptor
    Ras
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1698024-73-5
  • Formula Weight
    430.84
  • Molecular Formula
    C21H17ClF2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 290.13 mM
  • SMILES
    C=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F
  • Chemical Name
    1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Janes MR, et al. Cell. 2018 Jan 25;172(3):578-589.e17.
molnova catalog
related products
  • K-Ras G12C-IN-4

    K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C.

  • 6H05 trifluoroacetat...

    6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C)。

  • KRAS G12C inhibitor ...

    A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.