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AMP-PCP
CAS No. 3469-78-1
AMP-PCP( —— )
Catalog No. M21917 CAS No. 3469-78-1
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 50MG | 1782 | Get Quote |
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| 100MG | 2250 | Get Quote |
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Biological Information
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Product NameAMP-PCP
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NoteResearch use only, not for human use.
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Brief DescriptionAMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.
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DescriptionAMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90.AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.
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In VitroAMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP.
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In Vivo——
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP90
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Research Area——
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Indication——
Chemical Information
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CAS Number3469-78-1
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Formula Weight505.21
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Molecular FormulaC??H??N?O??P?
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Purity>98% (HPLC)
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Solubility——
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SMILESO[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O)=O)(O)=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.
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