JNJ-42253432

JNJ-42253432

Catalog No. M34298

JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.

Size Price / USD Stock Quantity
2MG 179 Get Quote
5MG 282 Get Quote
10MG 426 Get Quote
25MG 640 Get Quote
50MG 861 Get Quote
100MG 1116 Get Quote
500MG 2277 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    JNJ-42253432
  • Brief Description
  • Description
  • Storage
  • Note
    Research use only, not for human use.
  • Reference
    1. Brian Lord, et al. Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432. J Pharmacol Exp Ther. 2014 Dec;351(3):628-41.?
molnova catalog
related products
  • Gefapixant

    Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer).

  • AZD-9056

    A potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM.

  • Camlipixant

    Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive.