HIF-1 inhibitor-4
HIF-1 inhibitor-4
Catalog No. M35970
HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM. HIF-1 inhibitor-4 reduces the HIF-1α protein level without affecting its mRNA level.
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 112 | In Stock |
|
| 5MG | 92 | In Stock |
|
| 10MG | 151 | In Stock |
|
| 25MG | 281 | In Stock |
|
| 50MG | 445 | In Stock |
|
| 100MG | 687 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameHIF-1 inhibitor-4
-
Brief Description
-
Description
-
Storage
-
NoteResearch use only, not for human use.
-
Reference1. Nagao S, et al. Synthesis and structure-activity relationships of novel, potent, orally active hypoxia-inducible factor-1 inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5513-29. ?
molnova catalog
related products
-
M1002
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.
-
1,4-DPCA
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 μM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
-
TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
Cart
sales@molnova.com