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sAJM-589
CAS No. 2089-82-9
sAJM-589( sAJM589 )
Catalog No. M13273 CAS No. 2089-82-9
sAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 274 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamesAJM-589
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NoteResearch use only, not for human use.
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Brief DescriptionsAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM.
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DescriptionsAJM-589 is a novel, potent small molecule Myc inhibitor that disrupts the Myc-Max leucine-zipper heterodimer with IC50 of 1.8 uM; preferentially inhibits transcription of MYC target genes in P493-6 cell; suppresses cellular proliferation in diverse MYC-dependent cancer cell lines, including P493-6, Ramos, HL-60 and KG1a (IC50=0.8-2 uM); reduces Myc protein levels in these cells, possibly by promoting ubiquitination and degradation of Myc protein.
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In Vitro——
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In Vivo——
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SynonymssAJM589
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PathwayCell Cycle/DNA Damage
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Targetc-Myc
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Recptorc-Myc
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Research Area——
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Indication——
Chemical Information
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CAS Number2089-82-9
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Formula Weight246.269
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Molecular FormulaC16H10N2O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (20.30 mM)
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SMILESC1=CC=C2C(=C1)C(=CC3=NC4=CC=CC=C4N=C23)O
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Chemical NameBenzo[a]phenazin-5-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Choi SH, et al. ACS Chem Biol. 2017 Oct 4. doi: 10.1021/acschembio.7b00799.
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