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Zonampanel

CAS No. 210245-80-0

Zonampanel( YM 872 )

Catalog No. M13341 CAS No. 210245-80-0

Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Zonampanel
  • Note
    Research use only, not for human use.
  • Brief Description
    Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM.
  • Description
    Zonampanel (YM 872) is a selective, potent and highly water-soluble, competitive AMPA receptor (AMPAR) antagonist with Ki of 96 nM; shows very low affinity for other ionotropic glutamate receptors; competitively antagonizes kainate-induced currents in Xenopus laevis oocytes with a pA2 value of 6.97; exhibits great potential for treatment of neurodegenerative disorders such as stroke.Stroke Discontinued.
  • In Vitro
    Zonampanel inhibits the human MRP4-mediated transport of [3H]oestradiol 17-D-glucuronide in a concentration-dependent manner. In contrast, Zonampanel (up to 1000 mM) does not inhibit the human MRP2- or BCRP-mediated transport of [3H]oestradiol 17-D-glucuronide or [3H]methotrexate. Zonampanel inhibits the uptake of typical substrates by Oat1, Oat2, and Oat3 with inhibition constant (Ki) values of 7.02 to 10.4 μM. A time- and saturable concentration-dependent increase in [14C]Zonampanel uptake is observed in these cells [Km values: 13.4 to 53.6 μM].
  • In Vivo
    In in vivo experiments, probenecid and cimetidine decrease intrinsic clearance for both the renal secretion and biliary excretion of Zonampanel.
  • Synonyms
    YM 872
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    iGluR
  • Recptor
    iGluR
  • Research Area
    Neurological Disease
  • Indication
    Stroke

Chemical Information

  • CAS Number
    210245-80-0
  • Formula Weight
    331.241
  • Molecular Formula
    C13H9N5O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (150.95 mM)
  • SMILES
    O=C(O)CN1C(C(NC2=C1C=C(N3C=CN=C3)C([N+]([O-])=O)=C2)=O)=O
  • Chemical Name
    7-(1H-Imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalineacetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shimizu-Sasamata M, et al. Stroke. 1998 Oct;29(10):2141-8. 2. Takahashi M, et al. J Pharmacol Exp Ther. 1998 Feb;284(2):467-73. 3. Kohara A, et al. J Pharm Pharmacol. 1998 Jul;50(7):795-801.
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