Wy 49051
CAS No. 113418-56-7
Wy 49051( Wy-49051 )
Catalog No. M26508 CAS No. 113418-56-7
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 447 | Get Quote |
|
| 10MG | 651 | Get Quote |
|
| 25MG | 1017 | Get Quote |
|
| 50MG | 1368 | Get Quote |
|
| 100MG | 1782 | Get Quote |
|
| 500MG | 3573 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameWy 49051
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NoteResearch use only, not for human use.
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Brief DescriptionWy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
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DescriptionWy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).(In Vitro):Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM.(In Vivo):Wy 49051 shows against histamine-induced lethality in the guinea pig(ED50 of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv). The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment.
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In VitroWy 49051 shows great inhibitory effect on H1, producing 92% inhibition of the histamine-induced contraction of the guinea pig ileum at a concentration 100 nM. Wy 49051 is the most potent compound with 700 times the potency of astemazole, 470 times the potency of chlorpheniramine. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM.
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In VivoWy 49051 shows potent activity against histamine-induced lethality in the guinea pig, with ED50 of 1.91 mg/kg by po, 0.70 mg/kg by ip, and 0.01 mg/kg by iv. The duration of action of 24 is also favorable since there is no decrease in oral efficacy up to 18 h posttreatment.
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SynonymsWy-49051
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PathwayAngiogenesis
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TargetALK
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RecptorArenavirus
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Research Area——
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Indication——
Chemical Information
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CAS Number113418-56-7
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Formula Weight487.604
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Molecular FormulaC28H33N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCn1c2ncn(CCCN3CCC(CC3)OC(c3ccccc3)c3ccccc3)c2c(=O)n(C)c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47.
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