Wogonoside( Wogonoside | Oroxindin )

Catalog No. M18689 CAS No. 51059-44-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Wogonoside
Note

Research use only, not for human use.
Brief Description

Wogonoside acts as a?positive allosteric modulator?of the?benzodiazepine site of the?GABAA?receptor.
Description

Wogonoside is an antifungal agent isolated from Bacopa monnieri.
In Vitro

Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:100 μM Incubation Time:9-24 h Result:Increased the expression of LC3-II and Beclin-1 expression.Inhibited the phosphorylation levels of mTOR at Ser2448 and p70S6K at Ser-389.
In Vivo

Animal Model:MDA-MB-231 orthotopic modelDosage:80 mg/kg Administration:oral gavage, once every other day Result:Inhibited tumor growth (46%) and metastasis in brain, lung, liver and bone.Increased the expression of E-cadherin and reduced the expression of MMP-9, vimentin and Twist1 at ?orthotopic site.
Synonyms

Wogonoside | Oroxindin
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

GABA
Research Area

Cancer|Inflammation/Immunology
Indication

——

CAS Number

51059-44-0
Formula Weight

460.39
Molecular Formula

C22H20O11
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (271.51 mM)
SMILES

COc1c(cc(c2c1oc(cc2=O)c1ccccc1)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O
Chemical Name

5,7-Dihydroxy-8-methoxyflavone 7-O-beta-D-Glucuronide

1. Hui KM, et al. Biochem. Pharmacol. 2012, 64 (9): 1415–24.

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