Etoposide( EPE | NSC 141540 | VP-16-123 )

Catalog No. M14134 CAS No. 33419-42-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Etoposide
Note

Research use only, not for human use.
Brief Description

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
Description

Etoposide is a semisynthetic derivative of podophyllotoxin, which inhibits DNA synthesis via topoisomerase II inhibition activity.
In Vitro

Cell Viability Assay Cell Line:HCT116 FBXW+/+, FBXW-/- and p53-/- cells Concentration:0.025 μM, 0.05 μM, 0.075 μM, 0.1 μM, 0.2 μM, 0.4 μM, 0.6 μM, 0.8 μM, 1 μM Incubation Time:72 hours Result:Inhibits HCT116 FBXW+/+p>, FBXW-/- and p53-/- cell growth as a concentration manner.Western Blot Analysis Cell Line:HCT116 FBXW7+/+ or FBXW7-/- cells Concentration:25 μM Incubation Time:6 hours Result:Exhibited that the recovery of p53 levels after DNA damage is mediated by FBXW7.
In Vivo

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Synonyms

EPE | NSC 141540 | VP-16-123
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

Topo II
Research Area

Cancer
Indication

——

CAS Number

33419-42-0
Formula Weight

588.56
Molecular Formula

C29H32O13
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL (169.9 mM)
SMILES

O=C1OC[C@]2([H])C(O[C@H]3[C@H](O)[C@@H](O)[C@]4([H])O[C@H](C)OC[C@@]4([H])O3)C5=C(C=C6OCOC6=C5)[C@@H](C7=CC(OC)=C(O)C(OC)=C7)[C@]21[H]
Chemical Name

(5R,5aR,8aR)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

1.Berman HM, et al. Nucleic Acids Res. 2000 Jan 1; 28(1):235-42.

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