WYE-151650( —— )

Catalog No. M10503 CAS No. 1141855-86-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

WYE-151650
Note

Research use only, not for human use.
Brief Description

WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively.
Description

WYE-151650 is a novel potent, selective JAK3 inhibitor with IC50 of 0.8 nM, displays 36-, 14-, and 34-fold selectivity against JAK-1, JAK-2, and Tyk-2, respectively; inhibits IL-2-induced proliferation in human PBMC blasts with IC50 of 50 nM, inhibits IL-2-induced STAT-5 phosphorylation of lymphocytes, exhibits 10-29-fold less activity against JAK-3-independent IL-6- or GM-CSF-induced STAT phosphorylation; inhibits JAK-3-mediated IL-2-induced IFN-gamma production and decreases the natural killer cell population in mice, shows efficacy in mouse DTH and CIA models.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

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Indication

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CAS Number

1141855-86-8
Formula Weight

435.487
Molecular Formula

C26H21N5O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

1-[8,9-Dihydro-7-methyl-8-oxo-9-[(1R,4R)-1,2,3,4-tetrahydro-4-hydroxy-1-naphthalenyl]-7H-purin-2-yl]-1H-benzimidazole-6-carbonitrile

1. Lin TH, et al. Arthritis Rheum. 2010 Aug;62(8):2283-93.

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