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Vinorelbine
CAS No. 71486-22-1
Vinorelbine( KW-2307 )
Catalog No. M15731 CAS No. 71486-22-1
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 69 | In Stock |
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| 25MG | 139 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameVinorelbine
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NoteResearch use only, not for human use.
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Brief DescriptionVinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin.
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DescriptionVinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.Chemotherapeutic Agents Approved.
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In Vitro——
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In Vivo——
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SynonymsKW-2307
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorTubulinβchain
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Research AreaCancer
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IndicationChemotherapeutic
Chemical Information
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CAS Number71486-22-1
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Formula Weight778.9323
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Molecular FormulaC45H54N4O8
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCCC1=C[C@H]2C[C@@](C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC
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Chemical NameAspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rahmani R, et al. Cancer Chemother Pharmacol. 1986;16(3):223-8.
2. Ngan VK, et al. Mol Pharmacol. 2001 Jul;60(1):225-32.
3. Monnet I, et al. Eur J Cancer. 1991;27(12):1716-7.
4. Rahmani R, et al. Cancer Res. 1984 Dec;44(12 Pt 1):5609-13.
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