LR-510444( ELR510444 | ELR-510444 | ELR 510444. )

Catalog No. M10927 CAS No. 1233948-35-0

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Product Name

LR-510444
Note

Research use only, not for human use.
Brief Description

ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM.
Description

ELR510444 is a novel microtubule disruptor; inhibits MDA-MB-231 cell proliferation with IC50 of 30.9 nM; not a substrate for the P-glycoprotein drug transporter and retains activity in βIII-tubulin-overexpressing cell lines.
In Vitro

——
In Vivo

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Synonyms

ELR510444 | ELR-510444 | ELR 510444.
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule disruptor
Research Area

Cancer
Indication

——

CAS Number

1233948-35-0
Formula Weight

368.47
Molecular Formula

C19H16N2O2S2
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O=S(C1=CC=C(C)C=C1)(NC2=CC(C3=CC=C(C#N)S3)=CC=C2C)=O
Chemical Name

N-(5-(5-cyanothiophen-2-yl)-2-methylphenyl)-4-methylbenzenesulfonamide

1.Risinger AL, et al. J Pharmacol Exp Ther. 2011 Mar;336(3):652-60.

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