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Velpatasvir

CAS No. 1377049-84-7

Velpatasvir( GS-5816 | GS 5816 | GS5816 )

Catalog No. M11558 CAS No. 1377049-84-7

Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 95 In Stock
100MG 147 In Stock
200MG 219 In Stock
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Biological Information

  • Product Name
    Velpatasvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.
  • Description
    Velpatasvir (GS-5816) is a second generation, pan-genotypic inhibitor of HCV NS5A, demonstrates a high barrier to resistance in HCV replicon assays.HCV Infection Phase 3 Clinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:CCl4-induced non-HCV rat model Dosage:10 mg/kg/d alone, or in combination with Sofosbuvir (20 mg/kg/d) Administration:p.o.Result:Decreased the levels of TNF-a, NF-κB and IL-6 in serum and hepatic tissues.Inhibited hepatic stellate cells (HSCs).
  • Synonyms
    GS-5816 | GS 5816 | GS5816
  • Pathway
    Microbiology/Virology
  • Target
    HCV
  • Recptor
    HCVNS5A
  • Research Area
    Infection
  • Indication
    HCV Infection

Chemical Information

  • CAS Number
    1377049-84-7
  • Formula Weight
    883.0018
  • Molecular Formula
    C49H54N8O8
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 146.66 mg/mL (Need ultrasonic and warming)
  • SMILES
    O=C(OC)N[C@H](C1=CC=CC=C1)C(N2[C@H](C3=NC=C(C4=CC5=C(C6=CC7=CC=C8C(NC([C@H]9N(C([C@H](C(C)C)NC(OC)=O)=O)[C@@H](C)CC9)=N8)=C7C=C6OC5)C=C4)N3)C[C@H](COC)C2)=O
  • Chemical Name
    Carbamic acid, N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Curry MP, et al. N Engl J Med. 2015 Dec 31;373(27):2618-28. 2. Gane EJ, et al. Gastroenterology. 2016 Sep;151(3):448-456.e1. 3. Nakamoto S, et al. World J Gastroenterol. 2014 Mar 21;20(11):2902-12.
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