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NM107
CAS No. 20724-73-6
NM107( 2'-C-Methylcytidine | NM-107 | Valopicitabine )
Catalog No. M13224 CAS No. 20724-73-6
A nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 69 | In Stock |
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| 50MG | 141 | In Stock |
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| 100MG | 176 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNM107
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NoteResearch use only, not for human use.
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Brief DescriptionA nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells.
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DescriptionA nucleoside inhibitor of HCV NS5B polymerase with EC50 of 1.23 uM against HCV 1b replicon cells; The active component of NM283.HCV Infection Phase 2 Discontinued.
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In VitroRT-PCR Cell Line:Huh7-1 cells and cell culture-propagated HCV (HCVcc)Concentration:25 μM Incubation Time:24 hours Result:Extracellular virus titers declined in parallel with intracellular RNA levels.
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In Vivo——
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Synonyms2'-C-Methylcytidine | NM-107 | Valopicitabine
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCV
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number20724-73-6
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Formula Weight257.2432
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Molecular FormulaC10H15N3O5
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC[C@@H]1[C@H]([C@@]([C@H](N2C(N=C(C=C2)N)=O)O1)(C)O)O
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Chemical NameCytidine, 2'-C-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gardelli C, et al. J Med Chem. 2009 Sep 10;52(17):5394-407.
2. McCown MF, et al. Antimicrob Agents Chemother. 2008 May;52(5):1604-12.
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