USP10-IN-3( —— )

Catalog No. M16503 CAS No. 904448-58-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

USP10-IN-3
Note

Research use only, not for human use.
Brief Description

USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM).
Description

USP10-IN-3 is a HBX19818 analog, potent and selective USP10 inhibitor, but does not inhibit USP7 (IC50>100 uM); demonstrates specificity for FLT3- mutant MOLM13-luc+, MOLM14 and MV4,11 cell lines relative to the FLT3-null TF-1 cell line and to other leukemia lines not driven by FLT3.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

CAS Number

904448-58-4
Formula Weight

401.979
Molecular Formula

C23H32ClN3O
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCN(CCC)CCCNC(=O)C1=CC2=C(C=C1)C(=C3CCCCC3=N2)Cl
Chemical Name

9-chloro-N-(3-(dipropylamino)propyl)-5,6,7,8-tetrahydroacridine-3-carboxamide

1. Weisberg EL, et al. Nat Chem Biol. 2017 Dec;13(12):1207-1215.

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