Tyk2-IN-30( —— )

Catalog No. M11333 CAS No. 1334407-95-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Tyk2-IN-30
Note

Research use only, not for human use.
Brief Description

TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM.
Description

TYK2-IN-30 is a potent, selective and orally active Tyk2 inhibitor with Ki of 0.7 nM, exhibits excellent selectivity (35-fold for JAK1 and 83-fold for JAK3); potently inhibits IL-23 pathway in cells with EC50 of 66 nM, and has good pharmacokinetic properties; demonstrates dose-dependent reduction of IL-17 production in a PK/PD model as well as in an imiquimod-induced psoriasis model.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

JAK
Recptor

JAK
Research Area

——
Indication

——

CAS Number

1334407-95-2
Formula Weight

396.235
Molecular Formula

C18H11Cl2N7
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3,5-dichloro-4-(4-((6-methylpyrimidin-4-yl)amino)-3H-imidazo[4,5-c]pyridin-2-yl)benzonitrile

1. Liang J, et al. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4370-4376.

Calculator

molnova catalog