JAK-IN-11

Research use only, not for human use.

JAK-IN-11 is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.

JAK-IN-11 is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.(In Vitro):JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, ocular disorders and diseases, as well as in solid and hematologic malignancies such as leukemia and lymphomas.

JAK kinases are a family of cytoplasmic protein tyrosine kinases including JAK1, JAK2, JAK3 and TYK2. STAT proteins function both as signaling molecules and transcription factors and ultimately bind to specific DNA sequences present in the promoters of cytokine-responsive genes. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses such as allergies, asthma, autoimmune diseases such as transplant rejection, rheumatoid arthritis, amyotrophic lateral sclerosis and multiple sclerosis, ocular disorders and diseases, as well as in solid and hematologic malignancies such as leukemia and lymphomas.

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R-348

Angiogenesis

JAK

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916742-11-5

483.52

C23H22FN5O4S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (258.52 mM)

CCC(=O)NS(=O)(=O)c1cc(Nc2ncc(F)c(Nc3ccc(OCC#C)cc3)n2)ccc1C

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(-20℃)

With Ice Pack

≥ 2 years