Trimetrexate

Research use only, not for human use.

A quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor.

A quinazoline derivative and antifolate agent that fuctions as a dihydrofolate reductase (DHFR) inhibitor; shows activity against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate.Chemotherapeutic Agents Discontinued.

Cell Proliferation Assay Cell Line:SNU-C4 and NCI-H630 Concentration:0.1 mM Incubation Time:24 h Result:Inhibited cell growth by 50-60% in both cell lines. Cell Proliferation Assay Cell Line:C4 cells Concentration:1 and 10 mM Incubation Time:24 h Result:Produced 42% and 50% lethality at 1 and 10 mM, respectively.

Animal Model:Toxoplasma infected female BALB/c mice weighing about 20 gDosage:180 mg/kg or 30 mg/kg Administration:180 mg/kg per day orally in the drinking water or 30 mg/kg per day i.p.Result:Extended the median survival of the infected mice to 10 d (p.o.) or 19 d (i.p.).Animal Model:Charles River Wistar Crl(WI)BR rats weighing approximately 150 to 200 g Dosage:0, 1, 10, or 30 mg/kg Administration:Intravenous injection, once daily for 5 consecutive days followed by a 23-day recovery period Result:Showed chronic toxicity, the testicular changes persisting during the course of multiple cycles of dosing were not reversible within 21 days, but required an additional 56 days for essentially complete recovery.

CI-898 | NSC-249008 | CI898 | NSC249008

Cell Cycle/DNA Damage

Antifolate

Antifolate

Cancer

Chemotherapeutic

52128-35-5

369.4176

C19H23N5O3

>98% (HPLC)

10 mM in DMSO

NC1=NC(N)=C2C(C)=C(CNC3=CC(OC)=C(OC)C(OC)=C3)C=CC2=N1

2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-

(-20℃)

With Ice Pack

≥ 2 years