TNP-351( TNP351 )

Catalog No. M11069 CAS No. 125991-51-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

TNP-351
Note

Research use only, not for human use.
Brief Description

TNP-351 is an antifolate compound that functions as a DHFR inhibitor, strongly inhibits the growth of Meth A cells.
Description

TNP-351 is an antifolate compound that functions as a DHFR inhibitor, strongly inhibits the growth of Meth A cells.
In Vitro

TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively. The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively. Cell Viability Assay Cell Line:L1210 and CCRF-CEM cells Concentration:0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells Incubation Time:48 hours for L1210 cells; 72 hours for CCRF-CEM cells Result:The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
In Vivo

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Synonyms

TNP351
Pathway

Cell Cycle/DNA Damage
Target

Antifolate
Recptor

Antifolate
Research Area

——
Indication

——

CAS Number

125991-51-7
Formula Weight

440.46
Molecular Formula

C21H24N6O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CN=C3NC(N)=NC(N)=C32)C=C1)=O
Chemical Name

(2S)-2-[[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]amino]pentanedioic acid

1. Itoh F, et al. Cancer Chemother Pharmacol. 1994;34(4):273-9. 2. Itoh F, et al. Chem Pharm Bull (Tokyo). 1995 Feb;43(2):230-5.

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