Tretinoin

Research use only, not for human use.

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS.

An important regulator of gene expression during growth and development, and in neoplasm. Tretinoin, also known as retinoic acid and derived from maternal vitamin a, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin disease. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Retinoic acid (GMP) time- and dose- dependently induces differentiation of EC cells and ES cells into specific cell types.Retinoic acid (GMP) induces partial differentiation of F9 embryonal carcinoma cells into endoderm cells.Retinoic acid (GMP) (100 nM; 2-8 d) promotes photoreceptor differentiation in early postnatal retinal cultures.Retinoic acid (GMP) (0.1 μM; 10-12 d) induces human SH-SY5Y neuroblastoma cells differentiation with long cell processes. Retinoic acid (GMP) (0-10 μM; 48 h) dose-dependently induces morphologic differentiation of LA-N-1 human neuroblastoma cells.

Retinoic acid (GMP) (0.3 μM; embryos are immersed in tank water containing retinoic acid) accelerates of rod differentiation is observed following 24 and 48 hours of applicationin zebrafish.

atRA | NSC 122578 | NSC 122758 | RA | Vitamin A Acid

Metabolic Enzyme/Protease

Retinoid Receptor

RAR

Cancer

——

302-79-4

300.44

C20H28O2

>98% (HPLC)

Ethanol: 6 mg/mL (19.97 mM); DMSO: 60 mg/mL (199.73 mM)

O=C(O)/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid

(-20℃)

With Ice Pack

≥ 2 years