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Telaprevir
CAS No. 402957-28-2
Telaprevir( VX-950 | VX950 | VX 950 )
Catalog No. M14381 CAS No. 402957-28-2
A potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 87 | In Stock |
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| 10MG | 146 | In Stock |
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| 25MG | 233 | In Stock |
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| 50MG | 322 | In Stock |
|
| 100MG | 591 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTelaprevir
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM.
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DescriptionA potent, selective, covalent, orally bioavailable inhibitor of HCV NS3/4A protease with Ki of 7 nM; demonstrates excellent antiviral activity both in genotype 1b HCV replicon cells (IC50=354 nM) and in human fetal hepatocytes (IC50=280 nM); shows excellent viral inhibition in vivo with favorable pharmacokinetic profile.HCV Infection Approved.
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In Vitro——
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In Vivo——
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SynonymsVX-950 | VX950 | VX 950
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PathwayMicrobiology/Virology
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TargetHCV
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RecptorHCVNS3-4Aserineprotease
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Research AreaInfection
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IndicationHCV Infection
Chemical Information
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CAS Number402957-28-2
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Formula Weight679.8493
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Molecular FormulaC36H53N7O6
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C([C@@H]1[C@](CCC2)([H])[C@]2([H])CN1C([C@@H](NC([C@H](C3CCCCC3)NC(C4=NC=CN=C4)=O)=O)C(C)(C)C)=O)N[C@@H](CCC)C(C(NC5CC5)=O)=O
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Chemical NameCyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Perni RB, et al. Antimicrob Agents Chemother. 2006 Mar;50(3):899-909.
2. Lin C, et al. J Biol Chem. 2004 Apr 23;279(17):17508-14.
3. Lin C, et al. J Biol Chem. 2005 Nov 4;280(44):36784-91.
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