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TMP-153
CAS No. 128831-46-9
TMP-153( TMP153 )
Catalog No. M11175 CAS No. 128831-46-9
TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTMP-153
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NoteResearch use only, not for human use.
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Brief DescriptionTMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
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DescriptionTMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.Hypercholesterolemia Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTMP153
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PathwayOthers
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TargetOther Targets
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RecptorOther Targets
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Research AreaCardiovascular Disease
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IndicationHypercholesterolemia
Chemical Information
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CAS Number128831-46-9
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Formula Weight437.9
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Molecular FormulaC24H18ClF2N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC2=C(C(=CN=C2C=C1C)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl
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Chemical NameN-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.
2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.
3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.
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