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TGX-221

CAS No. 663619-89-4

TGX-221( TGX221 | TGX 221 )

Catalog No. M15529 CAS No. 663619-89-4

A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TGX-221
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM.
  • Description
    A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM; weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM); inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding; shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TGX221 | TGX 221
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    p110α|p110β|p110γ|p110δ
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    663619-89-4
  • Formula Weight
    364.4409
  • Molecular Formula
    C21H24N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1C=C(N2CCOCC2)N=C3N1C=C(C)C=C3C(NC4=CC=CC=C4)C
  • Chemical Name
    4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Frazzetto M, et al. Biochem J. 2008 Sep 15;414(3):383-90. 2. Sturgeon SA, et al. Eur J Pharmacol. 2008 Jun 10;587(1-3):209-15. 3. Chaussade C, et al. Biochem J. 2007 Jun 15;404(3):449-58. 4. Straub A, et al. Thromb Haemost. 2008 Mar;99(3):609-15.
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