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TASP0415914

CAS No. 1292300-75-4

TASP0415914( —— )

Catalog No. M21131 CAS No. 1292300-75-4

TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 132 Get Quote
5MG 222 Get Quote
10MG 357 Get Quote
25MG 597 Get Quote
50MG 851 Get Quote
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Biological Information

  • Product Name
    TASP0415914
  • Note
    Research use only, not for human use.
  • Brief Description
    TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
  • Description
    TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
  • In Vitro
    TASP0415914 (compound 8j) shows high metabolic stability in rat/human liver microsomes. TASP0415914 has no CYP inhibition up to 10 μM for CYP1A2, 2C9, 2C19, 2D6 and 3A4.
  • In Vivo
    TASP0415914 (compound 8j; 10-100 mg/kg; orally administration; twice daily; for 14 days) treatment suppressed the progression of the disease in a dose-dependent manner in a mouse collagen-induced arthritis (CIA) model. Animal Model:Collagen-primed DBA/1 mice Dosage:10 mg/kg; 30 mg/kg; 100 mg/kg.Administration:Orally administration; twice daily; for 14 daysResult:Suppressed the progression of the disease in a dose-dependent manner.
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    PI3Kγ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1292300-75-4
  • Formula Weight
    323.37
  • Molecular Formula
    C13H17N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (386.55 mM)
  • SMILES
    CC(=O)Nc1nc(C)c(-c2nc(N3CCCC(O)C3)no2)s1
  • Chemical Name
    N-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-yl}acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Oka Y Yabuuchi T Oi T et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-124-oxadiazol-5-yl]-4-methyl-13-thiazol-2-ylacetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases[J]. Bioorganic & Medicinal Chemistry 2013 21(24):7578-7583.
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