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GNE-490
CAS No. 1033739-92-2
GNE-490( GNE490 )
Catalog No. M10164 CAS No. 1033739-92-2
GNE-490 is a potent, selective, orally available class I PI3K inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
|
| 10MG | 507 | Get Quote |
|
| 25MG | 802 | Get Quote |
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| 50MG | 1107 | Get Quote |
|
| 100MG | 1503 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGNE-490
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NoteResearch use only, not for human use.
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Brief DescriptionGNE-490 is a potent, selective, orally available class I PI3K inhibitor.
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DescriptionGNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ; shows >200-fold selectivity over mTOR (IC50=740 nM); has good PK profiles, and are efficacious in xenograft models.
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In Vitro——
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In Vivo——
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SynonymsGNE490
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1033739-92-2
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Formula Weight386.474
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Molecular FormulaC18H22N6O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (258.75 mM)
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SMILESCC1=NC(=NC=C1C2=NC3=C(C(=N2)N4CCOCC4)SC(=C3)C(C)(C)O)N
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Chemical Name2-(2-Amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidine-6-methanol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sutherlin DP, et al. J Med Chem. 2010 Feb 11;53(3):1086-97.
2. Sampath D, et al. Neoplasia. 2013 Jul;15(7):694-711.
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