TAP-311( TAP311 )

Catalog No. M10527 CAS No. 1149362-88-8

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HNMR

HPLC

MSDS

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Product Name

TAP-311
Note

Research use only, not for human use.
Brief Description

TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
Description

TAP-311 is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM; displays >170-fold selectivity over CYPs, and has excellent pharmacokinetics in rats and robust efficacy in hamsters; shows substantially reduced lipophilicity with only modest distribution into adipose tissue, and retains potency in hypertriglyceridemic plasma in vitro and in vivo; does not increase blood pressure or plasma aldosterone levels in vivo, in contrast to torcetrapib.Dyslipidemia Phase 1 Clinical.
In Vitro

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In Vivo

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Synonyms

TAP311
Pathway

Metabolic Enzyme/Protease
Target

CETP
Recptor

CETP
Research Area

Cardiovascular Disease
Indication

Dyslipidemia

CAS Number

1149362-88-8
Formula Weight

710.72
Molecular Formula

C34H40F6N6O4
Purity

>98% (HPLC)
Solubility

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SMILES

CN1N=CC(C(C=N2)=CN=C2N(C3CC(CC)N(C(OC4CCC(C(O)=O)CC4)=O)C(CC)C3)CC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=C1
Chemical Name

4-((4-((3,5-bis(trifluoromethyl)benzyl)(5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)-2,6-diethylpiperidine-1-carbonyl)oxy)cyclohexane-1-carboxylic acid

1. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481.

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