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T-3775440
CAS No. 1422620-34-5
T-3775440( T 3775440 | T3775440 )
Catalog No. M11775 CAS No. 1422620-34-5
T-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameT-3775440
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NoteResearch use only, not for human use.
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Brief DescriptionT-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM.
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DescriptionT-3775440 is a novel potent, selecitve, irreversible LSD1 inhibitor with IC50 of 2.1 nM; displays high selectivity for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B); disrupts the interaction between LSD1 and growth factor-independent 1B (GFI1B) in leukemia cell lines, exhibites significant antitumor efficacy in AEL and AMKL xenograft models.
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In Vitro——
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In Vivo——
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SynonymsT 3775440 | T3775440
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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RecptorHistone Demethylase
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Research Area——
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Indication——
Chemical Information
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CAS Number1422620-34-5
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Formula Weight310.401
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Molecular FormulaC18H22N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1C=C(C=N1)C(=O)NC2=CC=C(C=C2)C3CC3NCC4CC4
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Chemical NameN-(4-((1S,2R)-2-((cyclopropylmethyl)amino)cyclopropyl)phenyl)-1-methyl-1H-pyrazole-4-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takagi S, et al. Cancer Res. 2017 Jun 30. pii: canres.3502.2016.
2. Ishikawa Y, et al. Mol Cancer Ther. 2017 Feb;16(2):273-284.
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